At the completion of this CME teaching activity, you should be able to:

• Discuss the most common diagnostic pitfalls in a diagnosis of well-differentiated lipomatous tumors
• Discuss the most common diagnostic entities in the differential diagnosis of myxoid, spindle cell, pleomorphic and round cell tumors
• Understand how to integrate clinical history, laboratory data, and imaging findings to come to a uniform diagnosis when presented with an unexpected histologic feature in a liver biopsy
• Recognize the liver tumors that can closely resemble hepatocellular carcinoma and the proper immunostain panel to identify that
• Identify the histologic features that allow for the diagnosis of Wilson disease, hereditary hemochromatosis, and alpha-1 antitrypsin deficiency
• Summarize the morphologic and molecular features of special histologic subtypes of triple negative breast cancer and management implications
• Review recent updates on biomarker testing in breast cancer
• Discuss diagnostic challenges in breast core needle biopsies and how to resolve these issues on difficult cases
• Describe the various histologic patterns of colitis and their differential diagnoses
• Recognize the key factors that predict prognosis and guide therapeutic decision making in colorectal cancer
• Classify appendiceal tumors according to updated criteria to guide subsequent therapy and predict prognosis
• To highlight common controversial topics in prostate pathology with a focus on grading and reporting parameters
• To review diagnostic challenges encountered in common bladder specimens
• To emphasize a practical approach to common diagnostic challenges in kidney tumors
• Discuss the most useful histologic and immunohistochemical findings in diagnosing serious neoplasms of the uterus and ovary, including a focus on HER2 testing
• Discuss some of the most common entities in cervical pathology seen in post-menopausal patients

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